- Promotes Restful Sleep
-
Supports Daytime Focus and Concentration
- Improves Sleep Quality and Next-Day Cognitive Function
Sleep & Perform features Shoden®, an ashwagandha extract with demonstrated benefits for supporting the restoration of sleep quality. Complemented with a proprietary blend of spearmint and green tea extract, this formula is designed to promote restful sleep and bolster daytime performance.
Take 2 capsules 30 minutes before bedtime, or use as directed by your healthcare professional.
Discussion
Sleep and Perform is a multifunctional formula designed to promote sleep
quality and support daytime focus and concentration. It features Shoden®
and Daily Zz™, a unique combination of ingredients demonstrated to
encourage restful sleep and support next-day cognitive function.*1,2
Shoden®
Ashwagandha (Withania somnifera) is classified as an “adaptogenic” herb,
indicating an ability to support how the body physiologically adapts.3,4 In
the Ayurvedic tradition, ashwagandha is considered a rasayana,5 meaning
it is used as a rejuvenator to achieve homeostasis, build vitality, and slow
degenerative- and senescence-related processes. For thousands of years,
ashwagandha has been used to help support people with ailments ranging
from musculoskeletal conditions to sleep issues.6,7 It is widely used today
for restoring physical and mental energy while balancing the effects of daily
stress.6,8 Analysis of ashwagandha has revealed that it contains a wide
range of biologically active chemical constituents collectively known as
withanolides.*9,10
Shoden is an extract derived from the leaves and roots of the ashwagandha
plant. This multipatented ashwagandha extract is distinguished by its
industry-leading concentration of 35% withanolide glycosides. Shoden has
been evaluated for its adaptogenic role in the stress response4,9 and for the
support of restful sleep.*1
To ascertain the effect of Shoden on restorative sleep, healthy subjects
(N = 150) were given 120 mg of Shoden daily for 6 weeks in a double-
blind, placebo-controlled study. Overall sleep quality was evaluated using
a weekly questionnaire and an assessment of parameters, such as sleep
latency, sleep efficiency, and total sleep time, as measured by a wearable
sleep actigraphy diagnostic monitoring device. A significant improvement in
sleep measures that define nonrestorative sleep was noted in the treatment
group when compared with the placebo, demonstrating the positive effect of
Shoden on encouraging restful sleep.*1
The mechanistic actions of Shoden and their potential impact on sleep were
assessed using in vitro and in vivo animal model experiments. Shoden was
found to have calming properties, including involvement in the induction
of sleep, GABA-mimetic action, non-REM sleep patterns, and slow-wave
electroencephalograph (EEG) cycles, suggesting potential for improving
sleep quality.*11
*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
Clinical Applications
» Promotes Restful Sleep*
» Supports Daytime Focus and Concentration*
» Improves Sleep Quality and Next-Day Cognitive Function*
Sleep & Perform features Shoden®, an ashwagandha extract with
demonstrated benefits for supporting the restoration of sleep quality.
Complemented with a proprietary blend of spearmint and green tea
extract, this formula is designed to promote restful sleep and bolster
daytime performance.*
Daily Zz™
Emerging evidence indicates that polyphenolic compounds in plants
may have benefits for sleep quality.2 Epigallocatechin gallate (EGCG), a
polyphenol compound found in green tea (Camellia sinensis), is well known
for its demonstrated antioxidant activity. In addition, EGCG also prolongs the
effects of GABA (gamma-aminobutyric acid), an inhibitory neurotransmitter
that plays a role in the relaxation of the central nervous system.12 This
occurs via positive allosteric modulation of the GABAA receptor by EGCG,
resulting in enhanced GABAA sensitivity.*12,13
Rosmarinic acid, found in plants of the Lamiaceae family, such as rosemary,
lemon balm, and mint, also influences GABA’s neurotransmitter activity
through positive allosteric modulation of the GABAA receptor. This results in
a mild inhibition of glutamate, the main excitatory neurotransmitter, which
may contribute to the effect of rosmarinic acid on sleep quality.2,14-16 In
addition, rosmarinic acid from plants, including spearmint (Mentha spicata),
has been reported to benefit cognitive performance and attention.15 An
inhibitory effect on the acetylcholinesterase and butyrylcholinesterase
enzymes responsible for breaking down acetylcholine, a neurotransmitter
that is crucial for cognitive functions such as learning, memory, and
attention, is thought to be a contributing factor.*17
A polyphenol-rich blend of spearmint and green tea extracts, known as
Daily Zz, has been studied for its benefit to sleep quality and next-day
cognitive function. In a randomized, double-blind study involving 89 subjects
with subclinical sleep disturbances, participants who received 485 mg/d of
Daily Zz for a 30-day trial period were assessed for improvements in sleep,
mood, and neurocognitive function. An improvement was noted in sleep
quality, as well as the ability to fall asleep, stay asleep, and wake refreshed,
as recorded by subjects in a sleep diary and with an activity tracker.
Additionally, improvement was noted in next-day focus and concentration,
indicating a role for improved sleep without compromising neurocognitive
function.*2
Magnesium
Although sometimes referred to as the relaxation mineral, magnesium has a
wide range of physiological functions. It is primarily known for its essential
role in more than 300 enzymatic biochemical reactions that regulate diverse
responses, including the transmission of nerve impulses across the central
nervous system. Magnesium also plays a mechanistic role in maintaining
cognitive function and is thought to benefit circadian rhythm and sleep
quality; however, further study is needed to verify these actions and
determine the optimal supplemental dose required to support these
functions.18,19 Magnesium is widely distributed in the food supply, yet
dietary surveys show that many individuals consume less than the
recommended amount.20 This formula provides 50 mg of magnesium (as
magnesium bisglycinate chelate) per serving, contributing 12% of the
recommended daily value (420 mg) for adults.*
Sleep and Perform combines Shoden® and Daily Zz™, complemented
by magnesium. This formula is designed to promote restful sleep and
support next-day cognitive function.*
Consult your healthcare professional prior to use. Individuals taking medication should discuss potential interactions with their healthcare professional. Do not use if tamper seal is damaged.
