Clinical applications:

Promotes Restful Sleep
Supports Daytime Focus and Concentration
Improves Sleep Quality and Next-Day Cognitive Function

Description:

Sleep & Perform features Shoden^®, an ashwagandha extract with demonstrated benefits for supporting the restoration of sleep quality. Complemented with a proprietary blend of spearmint and green tea extract, this formula is designed to promote restful sleep and bolster daytime performance.

Directions:

Take 2 capsules 30 minutes before bedtime, or use as directed by your healthcare professional.

Discussion

Sleep and Perform is a multifunctional formula designed to promote sleep

quality and support daytime focus and concentration. It features Shoden®

and Daily Zz™, a unique combination of ingredients demonstrated to

encourage restful sleep and support next-day cognitive function.*1,2

Shoden®

Ashwagandha (Withania somnifera) is classified as an “adaptogenic” herb,

indicating an ability to support how the body physiologically adapts.3,4 In

the Ayurvedic tradition, ashwagandha is considered a rasayana,5 meaning

it is used as a rejuvenator to achieve homeostasis, build vitality, and slow

degenerative- and senescence-related processes. For thousands of years,

ashwagandha has been used to help support people with ailments ranging

from musculoskeletal conditions to sleep issues.6,7 It is widely used today

for restoring physical and mental energy while balancing the effects of daily

stress.6,8 Analysis of ashwagandha has revealed that it contains a wide

range of biologically active chemical constituents collectively known as

withanolides.*9,10

Shoden is an extract derived from the leaves and roots of the ashwagandha

plant. This multipatented ashwagandha extract is distinguished by its

industry-leading concentration of 35% withanolide glycosides. Shoden has

been evaluated for its adaptogenic role in the stress response4,9 and for the

support of restful sleep.*1

To ascertain the effect of Shoden on restorative sleep, healthy subjects

(N = 150) were given 120 mg of Shoden daily for 6 weeks in a double-

blind, placebo-controlled study. Overall sleep quality was evaluated using

a weekly questionnaire and an assessment of parameters, such as sleep

latency, sleep efficiency, and total sleep time, as measured by a wearable

sleep actigraphy diagnostic monitoring device. A significant improvement in

sleep measures that define nonrestorative sleep was noted in the treatment

group when compared with the placebo, demonstrating the positive effect of

Shoden on encouraging restful sleep.*1

The mechanistic actions of Shoden and their potential impact on sleep were

assessed using in vitro and in vivo animal model experiments. Shoden was

found to have calming properties, including involvement in the induction

of sleep, GABA-mimetic action, non-REM sleep patterns, and slow-wave

electroencephalograph (EEG) cycles, suggesting potential for improving

sleep quality.*11

*These statements have not been evaluated by the Food and Drug Administration.

This product is not intended to diagnose, treat, cure, or prevent any disease.

Clinical Applications

» Promotes Restful Sleep*

» Supports Daytime Focus and Concentration*

» Improves Sleep Quality and Next-Day Cognitive Function*

Sleep & Perform features Shoden®, an ashwagandha extract with

demonstrated benefits for supporting the restoration of sleep quality.

Complemented with a proprietary blend of spearmint and green tea

extract, this formula is designed to promote restful sleep and bolster

daytime performance.*

Daily Zz™

Emerging evidence indicates that polyphenolic compounds in plants

may have benefits for sleep quality.2 Epigallocatechin gallate (EGCG), a

polyphenol compound found in green tea (Camellia sinensis), is well known

for its demonstrated antioxidant activity. In addition, EGCG also prolongs the

effects of GABA (gamma-aminobutyric acid), an inhibitory neurotransmitter

that plays a role in the relaxation of the central nervous system.12 This

occurs via positive allosteric modulation of the GABAA receptor by EGCG,

resulting in enhanced GABAA sensitivity.*12,13

Rosmarinic acid, found in plants of the Lamiaceae family, such as rosemary,

lemon balm, and mint, also influences GABA’s neurotransmitter activity

through positive allosteric modulation of the GABAA receptor. This results in

a mild inhibition of glutamate, the main excitatory neurotransmitter, which

may contribute to the effect of rosmarinic acid on sleep quality.2,14-16 In

addition, rosmarinic acid from plants, including spearmint (Mentha spicata),

has been reported to benefit cognitive performance and attention.15 An

inhibitory effect on the acetylcholinesterase and butyrylcholinesterase

enzymes responsible for breaking down acetylcholine, a neurotransmitter

that is crucial for cognitive functions such as learning, memory, and

attention, is thought to be a contributing factor.*17

A polyphenol-rich blend of spearmint and green tea extracts, known as

Daily Zz, has been studied for its benefit to sleep quality and next-day

cognitive function. In a randomized, double-blind study involving 89 subjects

with subclinical sleep disturbances, participants who received 485 mg/d of

Daily Zz for a 30-day trial period were assessed for improvements in sleep,

mood, and neurocognitive function. An improvement was noted in sleep

quality, as well as the ability to fall asleep, stay asleep, and wake refreshed,

as recorded by subjects in a sleep diary and with an activity tracker.

Additionally, improvement was noted in next-day focus and concentration,

indicating a role for improved sleep without compromising neurocognitive

function.*2

Magnesium

Although sometimes referred to as the relaxation mineral, magnesium has a

wide range of physiological functions. It is primarily known for its essential

role in more than 300 enzymatic biochemical reactions that regulate diverse

responses, including the transmission of nerve impulses across the central

nervous system. Magnesium also plays a mechanistic role in maintaining

cognitive function and is thought to benefit circadian rhythm and sleep

quality; however, further study is needed to verify these actions and

determine the optimal supplemental dose required to support these

functions.18,19 Magnesium is widely distributed in the food supply, yet

dietary surveys show that many individuals consume less than the

recommended amount.20 This formula provides 50 mg of magnesium (as

magnesium bisglycinate chelate) per serving, contributing 12% of the

recommended daily value (420 mg) for adults.*

Sleep and Perform combines Shoden® and Daily Zz™, complemented

by magnesium. This formula is designed to promote restful sleep and

support next-day cognitive function.*

Consult your healthcare professional prior to use. Individuals taking medication should discuss potential interactions with their healthcare professional. Do not use if tamper seal is damaged.

Storage:

Keep closed in a cool, dry place out of reach of children.

Formulated To Exclude:

Wheat, gluten, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, and artificial sweeteners.