Liposomal Glutathione 30 Capsules ~ Enhanced Glutathione Delivery*

Take 1 capsule 1-4 times daily, or use as directed by your healthcare professional.

Consult your healthcare professional before use. Individuals taking medication should discuss potential interactions with their healthcare professional. Do not use if tamper seal is damaged.

Keep closed in a cool, dry place out of reach of children.

Wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, and artificial sweeteners.

The tripeptide γ-L-glutamyl-L-cysteinylglycine, better known as

glutathione (GSH), is often referred to as the body’s master antioxidant.

Primarily synthesized in the liver by the sequential addition of cysteine

to glutamate followed by glycine, it can also be synthesized in nearly all

tissues of the body,1,2 and is present in millimolar concentrations in all

mammalian cells.3 Glutathione functions as a key intracellular antioxidant

in its reduced, active form, where it neutralizes free radicals and is

subsequently oxidized to glutathione disulfide (GSSG), then recycled back

to GSH, maintaining cellular redox homeostasis.*3

In addition to playing a key role as a direct antioxidant in managing

oxidative stress, GSH also has numerous other cellular functions, including

as a cofactor for enzymes in detoxification pathways, in the maintenance

of immune system function, for cell-cycle regulation, and the recycling of

other antioxidants and nutrients.*2,3

The maintenance of GSH tissue levels is critical for optimal health,2 and an

increased risk of numerous chronic conditions is linked to GSH depletion.

Many lifestyle and exposure factors can influence GSH levels in blood

and tissues, which vary widely across tissue types.2 To date, moderate

depletion of the intracellular GSH pool has been correlated with impaired

immune function, exposure to oxidants/drugs/toxins, poor nutrition that

limits availability of precursor amino acids, increases in oxidative stress

that occur with aging, and excessive exercise.*2,4,5

Antioxidant and Detoxification

As the master antioxidant, the primary role of GSH is to neutralize

reactive oxygen species (ROS), an umbrella term for a group of highly

reactive molecules that can be produced intra- and extra-cellularly. As

the drivers of oxidative stress, ROS can cause damage to proteins, lipids,

nucleic acids, and biological membranes. Glutathione helps to maintain

reduction-oxidation (redox) balance, the steady state between oxidation

and antioxidant protection that is essential for protecting from oxidative

damage that destabilizes tissues and accelerates cellular aging.1 In

addition to being a direct antioxidant, GSH also helps regenerate other key

antioxidants, particularly vitamins C and E. This recycling process enables

stronger, more efficient systemic antioxidant activity.*3

Glutathione also acts as a detoxification agent by conjugating with

toxins, drugs, and heavy metals through enzyme-mediated reactions. The

sulfhydryl group (−SH) of the cysteine moiety of GSH is the functional

component involved in conjugation and reduction reactions that facilitate

the removal of peroxides and many xenobiotic compounds,1 converting

undesirable molecules into water-soluble compounds that can then be

excreted from the body through bile or urine.*6

Cellular Functions

As an agent for redox balance, GSH plays a vital role in maintaining

mitochondrial function. By helping stabilize lipids within mitochondrial

membranes, it supports membrane integrity, slows mitochondrial aging,

and enables more efficient energy production while minimizing oxidative

damage.*1,7

Beyond its effects on mitochondrial health, GSH is involved in a wide

range of essential cellular processes, including protein folding, protection

of protein thiols from oxidation and crosslinking, enzyme regulation,

degradation of proteins containing disulfide bonds, and regulation

of the cell cycle and proliferation, underscoring its importance as a

multifunctional regulator of cellular health.*3

Immune Function

Exerting effects on both the innate and adaptive immune systems, GSH

plays a central role in supporting immune function. It has been shown to

enhance the activity of key immune cells, including natural killer (NK) and

T cells, which are critical for identifying and eliminating pathogens and

abnormal cells.8,9 Lymphocytes also require GSH to function effectively, as

even modest fluctuations in intracellular GSH can significantly influence

their behavior.*4

Continued on next page

*These statements have not been evaluated by the Food and Drug Administration.

This product is not intended to diagnose, treat, cure, or prevent any disease.

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Antioxidant Activity

Cell-Life Regulation

Detoxification

Immune System SupportAntioxidant Activity

Immune System Support Detoxification Cell-Life Regulation

Glutathione also protects immune cells from oxidative stress by neutralizing

ROS, thereby preserving cellular integrity and functionality. Some research

suggests that GSH supplementation may enhance NK cell activity and overall

immune function; however, there is limited indication that supplementation

further enhances immune function in healthy populations.2,4,8,9 What is

evident is that depletion of intracellular GSH has been shown to impact

immune cell function,4 underscoring its essential role in immune health.*

Glutathione Bioavailability

Because GSH is a critical antioxidant that readily shifts between its reduced

(active) and oxidized forms, effective supplementation may depend on

delivery method. Early research using oral GSH demonstrated minimal

improvements in cellular levels or oxidative stress markers, reinforcing

concerns about poor bioavailability. It was found that GSH is vulnerable to

enzymatic degradation in the gastrointestinal tract. This process can break

it down into precursor components and significantly limit the amount of

active GSH that is absorbed.10,11 Emerging evidence suggests that use of

liposomal technology, where GSH is encapsulated within lipid-based vesicles

(liposomes) that act as protective carriers, may resolve this limitation.

Liposomes help shield GSH from harsh digestive conditions and enzymatic

breakdown, allowing a greater proportion of the active compound to be

absorbed and potentially leading to improved clinical outcomes. Several

randomized, controlled trials have suggested that oral liposomal glutathione

supplementation increases systemic GSH levels, enhances antioxidant status,

and may support immune function.*2,8

In a randomized, double-blind, placebo-controlled trial in healthy adult

subjects (N = 54), daily doses of 250 and 1,000 mg of liposomal GSH given

over a 6-month period resulted in dose- and time-dependent increases in

GSH across whole blood, erythrocytes, plasma, lymphocytes, and buccal

cells, with levels returning to baseline after a 1-month washout period,

indicating a direct effect from supplementation. This study also reported

improved oxidative stress markers, including a lower oxidized-to-reduced

GSH ratio. Additionally, after 3 months of use at the higher dose, an increase

in NK cell cytotoxicity was observed, and although not statistically significant,

trending changes in lymphocyte activity were noted.*2

Similar results from a pilot study complement the prior study’s findings.

Healthy adult subjects (N = 12) were given oral liposomal GSH at 500 or

1,000 mg/day over a 1-month period. Dose-dependent increases in GSH

levels were noted within 1 week, with peak GSH elevations at 2 weeks of

up to 40% in whole blood and 100% in peripheral blood mononuclear cells.

These increases were accompanied by significant reductions in oxidative

stress biomarkers, including a 20% decrease in the oxidized-to-reduced

GSH ratio. Additionally, immune function improved markedly, with NK cell

cytotoxicity rising by up to 400% and lymphocyte proliferation increasing by

up to 60% within 2 weeks.*8

In further evidence of GSH’s ability to ameliorate oxidative stress, a 3-arm

trial was conducted to evaluate the effects of oral GSH in both its reduced

(GSH) and oxidized (GSSG) forms on skin biomarkers in healthy, middle-aged,

female subjects (N = 60) with a daily GSH dose of 250 mg over 12 weeks.

Participants received GSH, GSSG, or placebo, with assessments performed

at baseline and throughout the study period. Notably, GSH supplementation

led to significant reductions in wrinkle appearance at select anatomical

sites, while both forms of glutathione were associated with improvements

in skin elasticity across sun-exposed and protected areas. These findings

contribute to evidence suggesting a role for glutathione in modulating visible

signs of skin aging, likely a result of its antioxidant activity.12 Glutathione

supplementation may represent a practical, systemic approach that provides

essential antioxidant protection from the oxidative damage that accelerates

cellular aging.*1

Collectively, these studies contribute to the body of research

suggesting that oral liposomal GSH supplementation elevates both

intra- and extra-cellular GSH levels, reduces susceptibility to damage

from oxidative stress, and may favorably modulate immune cell

function. Liposomal GSH supplementation represents a promising

strategy for improving systemic GSH status, supporting overall health,

and potentially mitigating the risk for conditions associated with

glutathione depletion.*2,8

Liposomal Glutathione features 250 mg of Setria® glutathione,

a highly bioavailable form of the body’s master antioxidant.

This liposomal GSH formulation provides glutathione, a critical

intracellular antioxidant that is degraded by oxidative stress and

declines with age, to support the body’s antioxidant defense systems,

detoxification processes, and immune function.1,2,8 Although the

biological importance of GSH is well established and oral liposomal

supplementation has been shown to increase tissue levels, further

large-scale studies are warranted to determine optimal dosing and

to clarify the relationship between biomarker improvements and

meaningful clinical outcomes.*

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